Vitamin E ABSORPTION Study

This an IRB approved study on human participants looking at the speed and potency of absorption of Vitamin E between two different formulations.

Based in Tampa FL. Participants must be local residents. See details below.

 

STUDY BACKGROUND:

The study supplement is a patent-pending gel nutrient delivery technology that could provide enhanced bioavailability of nutrients given as dietary supplements, including vitamins, minerals, and botanical extracts, compared to pills (tablets or capsules). This technology is designed for maximum absorption by releasing extremely small, soluble nutrient particles in the digestive tract; solubility is a known surrogate for bioavailability. The bioavailability of a supplement may be limited by its ability to be solubilized within intestinal fluids. The bioavailability of these types of substances may therefore be improved by

utilizing food compositions or structures that enhance their intestinal solubility (McClements, Li, &

Xiao, 2015). The study supplement is designed as one such structure. In addition, the gel may protect the

dietary nutrients from chemical degradation in the stomach acid, which can further reduce bioavailability. The micronutrient that will be investigated in this protocol is vitamin E (as d-alpha-tocopherol succinate), which is essential for cellular function and maintaining homeostasis. Vitamin E, an essential fat-soluble nutrient, can be found in nutrient dense foods, but when required in supplement form, tablets or capsules often contain large, insoluble particles, inhibiting bioavailability. The study supplement pre-solubilizes nutrients in natural lipids in addition to other proprietary processes, designed for enhanced bioavailability.

 

The purpose of this study is to evaluate the bioavailability of vitamin E delivered via patent pending technology compared to a solid, dry 400 IU vitamin E tablet.

TO KNOW

IDEAL PARTICIPANT

  • AGE: 21-50 Years Old

  • Gender: Male & Female

  • Able to refrain from all other supplements for 2 weeks prior to the trial start and during

  • Able to participate in two 8 hour long visits one week apart. Participants can bring laptops, and other work or entertainment that is appropriate in a public setting.

  • Able to fast for 12-16 hours

  • Able to refrain from caffeine on testing days

  • BMI less than 30

  • Willingness and ability to have blood drawn via IV

CONTRAINDICATIONS

PARTICIPANTS CANNOT BE OR HAVE: :

  • A Smoker

  • Anemic

  • Cardiovascular issues

  • Metabolic Issues/ Diabetes

  • Blood disorders

  • On Supplements or medications that cannot be stopped for 2 weeks before the trial

  • Thyroid disorders

  • Other know nutrient deficiencies

  • Current Anabolic Steroid use

  • Be opposed to needles/IV blood draw

PROCESS & TESTING DETAILS

  • STEP 1 APPLY BY CLICKING HERE 

  • STEP 2 PRE-SCREENING APPT: (After we receive & review your application, if you are a good candidate on paper we will set your "pre-study" screening appointment; this will include paperwork, a simple finger prick for blood, blood pressure, weight, health history questionnaire).

  • STEP 3: TESTING DAY 1

    • you will be hooked up to an IV port for easy small blood draws at baseline, hours 2, 4 and 8. After Baseline blood work you will ingest the Vitamin supplement formulation #1.

    • You will be able to sit at a desk, recline in a chair or lie down throughout those 8 hours.

    • There is internet you can work off of. You will be given a standardized 400 calorie snack at hour 4. That will be the only food consumed during the 8 hours. 

  • STEP 4 - ONE WEEK WASH OUT - go home enjoy life but no other supplements for one week and you will track your food intake for 3 days prior to both testing dates

  • STEP 5 - TESTING DAY 2 - Return to ASPI for your second formulation - repeat protocol from Testing Day 1. (8 hours on site)

TESTING LOCATION:

Applied Science and Performance Institute (ASPI)

5850 W Cypress St Tampa, FL

The Two Testing Days will be your choice of

Testing Day 1 Options: October 28th or 29th

AND

Testing Day 2 Options: November 2nd or 3rd

Deadline for applying: October 20, 2021

Participation PERKS:

  • $225 Total pay (breakdown: $25 for pre-screening day, $100 per testing day. Paid by check at last visit.)

  • FREE DXA Scan ($250 value) - body composition

  • 30 day gym membership to ASPI (study program must be completed before beginning your membership. You may defer your membership start up to 90 days post study completion)

  • STEP 1 APPLY BY CLICKING HERE 

  • STEP 2 PRE-SCREENING APPT: (After we receive & review your application, if you are a good candidate on paper we will set your "pre-study" screening appointment; this will include paperwork, a simple finger prick for blood, blood pressure, weight, health history questionnaire).

  • STEP 3: TESTING DAY 1

    • you will be hooked up to an IV port for easy small blood draws at baseline, hours 2, 4 and 8. After Baseline blood work you will ingest the Vitamin supplement formulation #1.

    • You will be able to sit at a desk, recline in a chair or lie down throughout those 8 hours.

    • There is internet you can work off of. You will be given a standardized 400 calorie snack at hour 4. That will be the only food consumed during the 8 hours. 

  • STEP 4 - ONE WEEK WASH OUT - go home enjoy life but no other supplements for one week and you will track your food intake for 3 days prior to both testing dates

  • STEP 5 - TESTING DAY 2 - Return to ASPI for your second formulation - repeat protocol from Testing Day 1. (8 hours on site)

TESTING LOCATION:

Applied Science and Performance Institute (ASPI)

5850 W Cypress St

The Two Testing Days will be your choice of

Group A: October 26th & November 2nd 

OR

Group B: October 27th and November 3rd

(each group will receive both supplement formulations, there is no need for a placebo in this trial)

Deadline for applying: October 20, 2021